In many cases, secondary processes are also integrated with the electrospinning process so as to develop 3D TE scaffolds and overcome limitations in term of the nanofiber thickness. Various polymeric materials and their composites/blends have been successfully electrospun for tissue engineering (TE) scaffolds and they have been tabulated. Electrospinning of nano/micro scale poly(l-lactic acid) aligned fibers and their potential in neural tissue engineering Biomaterials, 26 ( 2005 ), pp. Hence, this review will reveal the fundamental working principles of electrospinning process and the effect of electrospinning process parameters towards the nanofibers morphology. Different applications might require nanofibers with specific criteria to be produced. Nanobiomaterials as bioinks play a key role in manipulating the cellular microenvironment to alter its growth and development. Contrary to the widely used solution electrospinning, the melt process is solvent-free and therefore volatility and toxicity issues associated with solvents can be avoided. Three-dimensional (3D) bioprinting has emerged as a promising scaffold fabrication strategy for tissue engineering with excellent control over scaffold geometry and microstructure. Although electrospinning is a simple process, there are still several parameters which need to be controlled or optimised in order to produce nanofibers with different characteristics. Melt electrospinning is an emerging fiber-based manufacturing technique that can be used to design and build scaffolds suitable for many tissue engineering (TE) applications. This is because nanofibers can replicate the structural design of natural human tissue at the nano-scale thus shortening the healing time. Most of the recent progress in tissue engineering has embarked on the use of nanofibers as tissue engineering scaffolds. The use of an electrospinning process in fabricating tissue engineering scaffolds has received great attention in recent years due to its simplicity and ability to fabricate ultrafine nanofibers. Electrospinning is a simple and efficient process in producing nanofibers. This review describes the state-of-the-art and unique perspectives of melt electrospinning and its writing applied to scaffold-based TE.© 2017 Nova Science Publishers, Inc. Moreover, in vivo studies show that scaffolds designed for specific tissue regeneration strategies performed superbly. In vitro studies have demonstrated that scaffolds designed and fabricated via MEW can support cell attachment, proliferation and extracellular matrix formation, as well as cell infiltration throughout the thickness of the scaffold facilitated by the large pores and pore interconnectivity. Tissue engineering (TE) holds an enormous potential to develop functional scaffolds resembling the structural organization of native tissues, to improve or replace biological functions and prevent organ transplantation. This in turn permits a precise and predictable fiber deposition in the combination with moving collectors, termed melt electrospinning writing (MEW), allows the layer-by-layer fabrication of small to large volume scaffolds with specific designs, shapes and thicknesses. Furthermore, molten polymers are often viscous and nonconductive, making them candidates for generating electrospinning jets without electrical instabilities. Thanks to these characteristics, wet electrospinning can be employed in a wide range of tissue engineering and industrial applications. Contrary to the widely used solution electrospinning, the melt process is solvent-free and therefore volatility and toxicity issues associated with solvents can be avoided. Melt electrospinning is an emerging fiber-based manufacturing technique that can be used to design and build scaffolds suitable for many tissue engineering (TE) applications.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |